List of U.S. Domestic Flights — Major Routes by Airline

List of Major U.S. Domestic Flights

A helpful directory of common domestic flight routes operated by major U.S. airlines.

This list includes popular domestic routes across major U.S. airlines. For full and updated schedules, visit the airline websites linked below.

American Airlines

  • New York (JFK) → Los Angeles (LAX)
  • Miami (MIA) → Chicago (ORD)
  • Dallas/Fort Worth (DFW) → New York (LGA)
  • Charlotte (CLT) → Denver (DEN)
  • Phoenix (PHX) → Seattle (SEA)

Delta Air Lines

  • Atlanta (ATL) → New York (JFK)
  • Detroit (DTW) → Orlando (MCO)
  • Salt Lake City (SLC) → San Francisco (SFO)
  • Minneapolis (MSP) → Phoenix (PHX)
  • Los Angeles (LAX) → Honolulu (HNL)

United Airlines

  • Chicago (ORD) → Houston (IAH)
  • Denver (DEN) → Las Vegas (LAS)
  • San Francisco (SFO) → San Diego (SAN)
  • Washington Dulles (IAD) → Miami (MIA)
  • Los Angeles (LAX) → Newark (EWR)

Southwest Airlines

  • Dallas Love Field (DAL) → Denver (DEN)
  • Chicago Midway (MDW) → Phoenix (PHX)
  • Las Vegas (LAS) → Oakland (OAK)
  • Houston (HOU) → Orlando (MCO)
  • Los Angeles (LAX) → Sacramento (SMF)

JetBlue Airways

  • Boston (BOS) → Washington (DCA)
  • New York (JFK) → Fort Lauderdale (FLL)
  • Orlando (MCO) → San Juan (SJU)
  • Los Angeles (LAX) → Salt Lake City (SLC)
  • Tampa (TPA) → New York (LGA)

Alaska Airlines

  • Seattle (SEA) → Los Angeles (LAX)
  • Portland (PDX) → San Francisco (SFO)
  • Anchorage (ANC) → Seattle (SEA)
  • San Diego (SAN) → Boise (BOI)
  • San Jose (SJC) → Orange County (SNA)

Frontier Airlines

  • Denver (DEN) → Las Vegas (LAS)
  • Orlando (MCO) → Philadelphia (PHL)
  • Miami (MIA) → Atlanta (ATL)
  • Phoenix (PHX) → Denver (DEN)
  • Chicago (ORD) → Tampa (TPA)

Spirit Airlines

  • Fort Lauderdale (FLL) → Atlanta (ATL)
  • Las Vegas (LAS) → Los Angeles (LAX)
  • Detroit (DTW) → Orlando (MCO)
  • Houston (IAH) → Las Vegas (LAS)
  • Baltimore (BWI) → Tampa (TPA)